Resveratrol Anti Aging

Nora asked:


i have to write a paper about it for chem class, so my teacher is looking for how it works in the body. since its chem class, she wants the chemistry behind it, not just the biology (e.g. helping mitochondria or ant-inflammatory for arteries). any knowledge would be awesome!

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March_Hare asked:


I am looking for a Resveratrol-like Pyridine (or piperidine, pyrone or lactone) that will bind/activate specific sirtuins with higher affinity by having a nitrogen (or oxygen) in one of the two rings (I’m assuming in the (3?) position opposite the ethylene group) so I can see if it also extends lifespan (& look at any HDAC interactions w/ butyric acid.)
The Kavalactone yangonin is close, but (like lobelia alkaloids) has this in position (1?)

I’ve looked at some others, variations on pyritinol or metal-binding ligands, some betalain & cyanine dyes, aroma/flavor compounds, (C6H6O2/3)-isonicotinates, even ICRF 193 or Diammonium EDTA, but since

this is start-up/free-lance work, I don’t even know where to get this kind of stuff (OTC would be better than a supplier) let alone how test the senescence of organisms in culture.
Any ideas on sources, or help with applicable organic synthesis, would be much appreciated.
Thanks Nathan, I definitely will look at that article. Here’s a related one.. http://www.nature.com/nature/journal/v450/n7170/fig_tab/nature06261_F1.html
Paxil has that conformation too, like isonicotinate another antidepressant.
Still trying to get my hands on that article…
Well, based on the success of SRT1720, I may just run with amide of kavalactone as a target, see where it gets me. It’s a start.

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